Insm1 - insulinoma-associated 1 Gene

Mus musculus

Also known as IA-1

Gene ID: 53626 | Gene type: protein coding

About Insm1

Summary

Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and cyclin binding activity. Involved in several processes, including glandular epithelial cell differentiation; nervous system development; and norepinephrine biosynthetic process. Acts upstream of or within positive regulation of cell migration; positive regulation of cell population proliferation; and type B pancreatic cell development. Located in nucleus. Is expressed in several structures, including adrenal gland; branchial arch; gut; nervous system; and sensory organ. Orthologous to human INSM1 (INSM transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Insm1 Products(1)

mRNA	Protein	Name
NM_016889.4	NP_058585.2	insulinoma-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12079283	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adrenal chromaffin cell differentiation	IMP IMP: Inferred from mutant phenotype	18094025	MGI
acts upstream of cell migration	IMP IMP: Inferred from mutant phenotype	25053427	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25053427	MGI
acts upstream of or within endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	16511571	MGI
acts upstream of or within endocrine system development	IMP IMP: Inferred from mutant phenotype	16951258	MGI
involved in noradrenergic neuron development	IMP IMP: Inferred from mutant phenotype	18094025	MGI
involved in norepinephrine biosynthetic process	IMP IMP: Inferred from mutant phenotype	18094025	MGI
involved in pancreatic A cell differentiation	IDA IDA: Inferred from direct assay	16511571	MGI
acts upstream of or within pancreatic A cell differentiation	IMP IMP: Inferred from mutant phenotype	16511571	MGI
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	18094025	MGI
acts upstream of or within positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	25053427	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25053427	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	18094025	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18094025	MGI
involved in sympathetic ganglion development	IMP IMP: Inferred from mutant phenotype	18094025	MGI
acts upstream of or within type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	16951258	MGI
involved in type B pancreatic cell differentiation	IDA IDA: Inferred from direct assay	16511571	MGI
acts upstream of or within type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	16511571	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12079283	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulinoma-associated protein 1

insulinoma-associated protein (IA-1)

zinc finger protein IA-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06844	INSM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20042	Insm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26545	Insm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Insm1	NCBI	NCBI:3642

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