Sco1 - SCO1 cytochrome c oxidase assembly protein Gene

Mus musculus

Also known as D11Bwg1310e; 2610001C07Rik

Gene ID: 52892 | Gene type: protein coding

About Sco1

Summary

Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including cyclooxygenase pathway; mitochondrial cytochrome c oxidase assembly; and negative regulation of protein kinase B signaling. Located in mitochondrion. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; submandibular gland primordium; and vascular element. Used to study cytochrome-c oxidase deficiency disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human SCO1 (synthesis of cytochrome C oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sco1 Products(1)

mRNA	Protein	Name
NM_001040026.1	NP_001035115.1	protein SCO1 homolog, mitochondrial

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within copper ion homeostasis	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within cyclooxygenase pathway	IMP IMP: Inferred from mutant phenotype	28973536	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within intracellular copper ion homeostasis	IDA IDA: Inferred from direct assay	28647369	MGI
acts upstream of or within intracellular copper ion homeostasis	IMP IMP: Inferred from mutant phenotype	25683716	MGI
acts upstream of or within intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within mitochondrial cytochrome c oxidase assembly	IMP IMP: Inferred from mutant phenotype	25683716	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within negative regulation of cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	28973536	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	28647369	MGI
acts upstream of or within negative regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	25683716	MGI
acts upstream of or within post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	28973536	MGI
acts upstream of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	25683716	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	28973536	MGI
acts upstream of or within protein secretion	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	28973536	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	36301669	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	36301669	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	19837698	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein SCO1 homolog, mitochondrial

SCO cytochrome oxidase deficient homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12556	SCO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19161	Sco1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25650	Sco1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sco1	NCBI	NCBI:6341

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