Hnrnpu - heterogeneous nuclear ribonucleoprotein U Gene

Mus musculus

Also known as SAFA; Hnrpu; Sp120; hnRNP U

Gene ID: 51810 | Gene type: protein coding

About Hnrnpu

Summary

Enables RNA polymerase II C-terminal domain binding activity; nucleic acid binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including RNA localization to chromatin; cellular response to leukemia inhibitory factor; and regulation of gene expression. Acts upstream of or within with a positive effect on mRNA metabolic process. Acts upstream of or within cardiac muscle cell development. Located in inactive sex chromosome and nucleus. Part of ribonucleoprotein complex. Is expressed in several structures, including branchial arch; future brain; limb primordium; tail bud; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpu Products(1)

mRNA	Protein	Name
NM_016805.3	NP_058085.2	heterogeneous nuclear ribonucleoprotein U

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	20833368	MGI
enables RNA binding	IPI IPI: Inferred from physical interaction	25921091	MGI
enables RNA polymerase II C-terminal domain binding	IDA IDA: Inferred from direct assay	21235343	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18332112	MGI
enables lncRNA binding	IDA IDA: Inferred from direct assay	25921091	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	21235343	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18495661	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21235343	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA localization to chromatin	IMP IMP: Inferred from mutant phenotype	20833368	MGI
involved in adaptive thermogenesis	IMP IMP: Inferred from mutant phenotype	28784777	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	26039991	MGI
involved in cellular response to leukemia inhibitory factor	IDA IDA: Inferred from direct assay	21235343	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	18332112	MGI
involved in dendritic transport of messenger ribonucleoprotein complex	IDA IDA: Inferred from direct assay	15312650	MGI
involved in dendritic transport of messenger ribonucleoprotein complex	IMP IMP: Inferred from mutant phenotype	15312650	MGI
involved in dosage compensation by inactivation of X chromosome	IMP IMP: Inferred from mutant phenotype	20833368	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	28636939	MGI
acts upstream of or within positive effect mRNA metabolic process	IMP IMP: Inferred from mutant phenotype	25921091	MGI
involved in negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	21235343	MGI
involved in positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	28784777	MGI
involved in positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20833368	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22162999	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21235343	MGI
involved in random inactivation of X chromosome	IMP IMP: Inferred from mutant phenotype	25915022	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in inactive sex chromosome	IDA IDA: Inferred from direct assay	20833368	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18332112	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	25921091	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein U

heterogenous nuclear ribonucleoprotein U	nuclear matrix protein sp120
scaffold attachment factor A

Hnrnpu Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hnrnpu	Q8VEK3	Smarca4	Mus musculus	Q3TKT4	PLA	22162999

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS06278	HNRNPU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21138	Hnrnpu Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27656	Hnrnpu Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnrnpu	NCBI	NCBI:3192

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