Bok - BCL2-related ovarian killer Gene

Mus musculus

Also known as mtd; matador

Gene ID: 51800 | Gene type: protein coding

About Bok

Summary

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; ion homeostasis; and regulation of programmed cell death. Acts upstream of or within neuron apoptotic process. Located in several cellular components, including bounding membrane of organelle; mitochondrial membrane; and trans-Golgi network membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; retina; and vibrissa dermal component. Orthologous to human BOK (BCL2 family Apoptosis regulator BOK). [provided by Alliance of Genome Resources, Apr 2022]

Bok Products(1)

mRNA	Protein	Name
NM_016778.3	NP_058058.1	bcl-2-related ovarian killer protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23884412	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23429263	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	23884412	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	26949185	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IMP IMP: Inferred from mutant phenotype	26015568	MGI
involved in cellular component disassembly involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	23429263	MGI
involved in negative regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	27098698	MGI
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27098698	MGI
involved in negative regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	27098698	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	27098698	MGI
acts upstream of or within neuron apoptotic process	IDA IDA: Inferred from direct assay	9535847	MGI
involved in positive regulation of PERK-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	26015568	MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	26949185	MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	26015568	MGI
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	23429263	MGI
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	26949185	MGI
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	26949185	MGI
involved in regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	27098698	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cis-Golgi network membrane	IDA IDA: Inferred from direct assay	23429263	MGI
located in early endosome membrane	IDA IDA: Inferred from direct assay	23429263	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23429263	MGI
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	23429263	MGI
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	23429263	MGI
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	23429263	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bcl-2-related ovarian killer protein

apoptosis activator Mtd

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01570	BOK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18323	Bok Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24801	Bok Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bok	NCBI	NCBI:666

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