Ppp2r1a - protein phosphatase 2, regulatory subunit A, alpha Gene

Mus musculus

Also known as PP2A; PR65; 6330556D22Rik

Gene ID: 51792 | Gene type: protein coding

About Ppp2r1a

Summary

Enables protein serine/threonine Phosphatase activity. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and glutamatergic synapse. Part of protein Phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 36. Orthologous to human PPP2R1A (protein Phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2r1a Products(1)

mRNA	Protein	Name
NM_016891.3	NP_058587.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12885400	MGI
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	12944463	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	26974206	MGI
acts upstream of or within female meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	24899574	MGI
acts upstream of or within meiotic sister chromatid cohesion, centromeric	IMP IMP: Inferred from mutant phenotype	24899574	MGI
acts upstream of or within meiotic spindle elongation	IMP IMP: Inferred from mutant phenotype	24899574	MGI
acts upstream of or within mitotic sister chromatid separation	IMP IMP: Inferred from mutant phenotype	24899574	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	26974206	MGI
acts upstream of or within peptidyl-serine dephosphorylation	IDA IDA: Inferred from direct assay	12944463	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	12944463	MGI
acts upstream of or within regulation of meiotic cell cycle process involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	24899574	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	12885400	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	24413018	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24413018	MGI
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	16717086	MGI
is active in synapse	EXP EXP: Inferred from Experiment	16452087	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16452087	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

protein phosphatase PP2A

serine/threonine protein phosphatase A subunit type 2A

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11009	PPP2R1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18724	Ppp2r1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25211	Ppp2r1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp2r1a	NCBI	NCBI:5518

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