2. Gene
  3. Dlc1 - deleted in liver cancer 1 Gene

Dlc1 - deleted in liver cancer 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HP; dlc-1; Arhgap7; STARD12; A730069N07Rik

Gene ID: 50768 | Gene type: protein coding

About Dlc1

Summary

Predicted to enable several functions, including GTPase activator activity; SH2 domain binding activity; and Phospholipase binding activity. Acts upstream of or within several processes, including actin Cytoskeleton organization; focal adhesion assembly; and nervous system development. Predicted to be located in several cellular components, including caveola; cortical actin cytoskeleton; and ruffle membrane. Predicted to be active in focal adhesion and membrane raft. Predicted to colocalize with actin filament and stress fiber. Is expressed in several structures, including central nervous system; liver; mandible; placenta; and trigeminal nerve. Human ortholog(s) of this gene implicated in colorectal Cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]

Dlc1 Products(3)

mRNA Protein Name
NM_001194940.2 NP_001181869.1 rho GTPase-activating protein 7 isoform 1
NM_001194941.1 NP_001181870.1 rho GTPase-activating protein 7 isoform 3
NM_015802.3 NP_056617.2 rho GTPase-activating protein 7 isoform 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15710412 MGI
acts upstream of or within focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
15710412 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15710412 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
15710412 MGI
acts upstream of or within hindbrain morphogenesis IMP
IMP: Inferred from mutant phenotype
15710412 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
15710412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho GTPase-activating protein 7

START domain-containing protein 12

p122-RhoGAP

rho-type GTPase-activating protein 7

stAR-related lipid transfer protein 12

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03793 DLC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19126 Dlc1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25616 Dlc1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlc1 NCBI NCBI:10395