2. Gene
  3. Elane - elastase, neutrophil expressed Gene

Elane - elastase, neutrophil expressed Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NE; Ela2; F430011M15Rik

Gene ID: 50701 | Gene type: protein coding

About Elane

Summary

This gene encodes a member of the chymotrypsin-like family of serine protease Enzymes that hydrolyzes a broad range of protein substrates including elastin. This gene is expressed by neutrophils where the encoded enzyme is stored in azurophil granules. Upon neutrophil activation, the active enzyme is released into the extracellular mileu. Mice lacking the encoded protein exhibit increased susceptibility to sepsis and death following intraperitoneal Infection with Gram negative bacteria. This gene is located adjacent to a related proteinase gene on chromosome 10. [provided by RefSeq, Jul 2016]

Elane Products(1)

mRNA Protein Name
NM_015779.2 NP_056594.2 neutrophil elastase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17878334 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within acute inflammatory response to antigenic stimulus IDA
IDA: Inferred from direct assay
17878334 MGI
acts upstream of or within defense response to fungus IGI
IGI: Inferred from genetic interaction
10714686 MGI
acts upstream of or within defense response to fungus IMP
IMP: Inferred from mutant phenotype
10714686 MGI
acts upstream of or within leukocyte migration IMP
IMP: Inferred from mutant phenotype
15034066 MGI
acts upstream of or within neutrophil-mediated killing of fungus IMP
IMP: Inferred from mutant phenotype
11907569 MGI
acts upstream of or within phagocytosis IMP
IMP: Inferred from mutant phenotype
15034066 MGI
acts upstream of or within positive regulation of immune response IGI
IGI: Inferred from genetic interaction
10714686 MGI
acts upstream of or within positive regulation of immune response IMP
IMP: Inferred from mutant phenotype
10714686 MGI
acts upstream of or within response to lipopolysaccharide IGI
IGI: Inferred from genetic interaction
10714686 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
10714686 MGI
acts upstream of or within response to yeast IMP
IMP: Inferred from mutant phenotype
11907569 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17878334 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil elastase

elastase 2, neutrophil

leukocyte elastase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04292 ELANE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17227 Elane Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23680 Elane Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Elane NCBI NCBI:1991