2. Gene
  3. Slc6a8 - solute carrier family 6 member 8 Gene

Slc6a8 - solute carrier family 6 member 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CRT; CT1; CHT1; CHOT1

Gene ID: 50690 | Gene type: protein coding

About Slc6a8

Summary

Enables choline transmembrane transporter activity and creatine:sodium symporter activity. Involved in creatine transmembrane transport and embryonic brain development. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in creatine transporter deficiency and intellectual disability. Orthologous to human SLC6A8 (solute carrier family 6 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a8 Products(1)

mRNA Protein Name
NM_017348.3 NP_059044.1 sodium- and chloride-dependent creatine transporter 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables choline transmembrane transporter activity IDA
IDA: Inferred from direct assay
1633856 RGD
enables creatine transmembrane transporter activity IDA
IDA: Inferred from direct assay
8297374 RGD
enables creatine:sodium symporter activity IDA
IDA: Inferred from direct assay
8297374 RGD
Biological Process GO Annotation Evidence Reference Source
involved in creatine transmembrane transport IDA
IDA: Inferred from direct assay
8297374 RGD
involved in embryonic brain development IEP
IEP: Inferred from expression pattern
15918910 RGD
involved in protein catabolic process EXP
EXP: Inferred from Experiment
20731764 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
20731764 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12433955 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20731764 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
32115505 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
20731764 RGD
is active in synapse EXP
EXP: Inferred from Experiment
20731764 RGD
is active in synapse IDA
IDA: Inferred from direct assay
20731764 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium- and chloride-dependent creatine transporter 1

choline transporter

creatine transporter 1

solute carrier family 6 (neurotransmitter transporter), member 8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W015828 Ompenaclid Inducer 99.89% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-169294 SLC6A8 corrector 1 Inhibitor / Unkown
HY-169295 RAP 1 / Unkown
HY-RS13319 SLC6A8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17671 Slc6a8 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24132 Slc6a8 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a8 NCBI NCBI:6535