L1cam - L1 cell adhesion molecule Gene

Rattus norvegicus

Also known as Hyd; Hsas; NgCAM; NCAML1; N-CAM L1

Gene ID: 50687 | Gene type: protein coding

About L1cam

Summary

Enables PDZ domain binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and generation of neurons. Located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse. Used to study hydrocephalus. Biomarker of anxiety disorder; hypothyroidism; and mental depression. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

L1cam Products(1)

mRNA	Protein	Name
NM_017345.2	NP_059041.2	neural cell adhesion molecule L1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	11152476	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18519736	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	3856258	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	1377284	RGD
NOT involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	18926887	RGD
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	21884525	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	3511068	RGD
involved in cellular response to thyroxine stimulus	IEP IEP: Inferred from expression pattern	11085884	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	16686695	RGD
involved in cerebellar neuron development	IMP IMP: Inferred from mutant phenotype	27027721	RGD
involved in dopaminergic neuron differentiation	IEP IEP: Inferred from expression pattern	1350253	RGD
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	7997264	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	7997264	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	24841827	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	18519736	RGD
involved in positive regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	8636223	RGD
involved in protein localization to plasma membrane raft	IDA IDA: Inferred from direct assay	27027721	RGD
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16478533	RGD
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	27027721	RGD
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	27027721	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	12499861	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	11085884	RGD
involved in response to toluene	IDA IDA: Inferred from direct assay	27027721	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	7997264	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	7997264	RGD
located in axon	IDA IDA: Inferred from direct assay	18299352	RGD
located in axonal growth cone	IDA IDA: Inferred from direct assay	15355311	RGD
located in cell surface	IDA IDA: Inferred from direct assay	18299352	RGD
located in dendrite	IDA IDA: Inferred from direct assay	18299352	RGD
located in dendritic growth cone	IDA IDA: Inferred from direct assay	15355311	RGD
located in endosome	IDA IDA: Inferred from direct assay	18299352	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18299352	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neural cell adhesion molecule L1

N-CAM-L1	NCAM-L1
NILE	nerve-growth factor-inducible large external glycoprotein
neuron-glia cell adhesion molecule

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07481	L1CAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18070	L1cam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24545	L1cam Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	L1cam	NCBI	NCBI:3897
Mus musculus	L1cam	NCBI	NCBI:16728

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