2. Gene
  3. Prf1 - perforin 1 Gene

Prf1 - perforin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cyta; RATCYTA

Gene ID: 50669 | Gene type: protein coding

About Prf1

Summary

Predicted to enable calcium ion binding activity; identical protein binding activity; and wide pore channel activity. Involved in apoptotic process; circadian rhythm; and response to ethanol. Located in cytoplasmic vesicle and extracellular space. Used to study asthma; colon carcinoma; and glomerulonephritis. Biomarker of membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1). [provided by Alliance of Genome Resources, Apr 2022]

Prf1 Products(1)

mRNA Protein Name
NM_017330.2 NP_059026.2 perforin-1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
16309885 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
14978081 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
17622272 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

perforin-1

P1

cytolysin

lymphocyte pore-forming protein

perforin 1 (pore forming protein)

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11087 PRF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16136 ZNF395 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19938 Prf1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26440 Prf1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prf1 NCBI NCBI:5551