2. Gene
  3. Runx1 - RUNX family transcription factor 1 Gene

Runx1 - RUNX family transcription factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Aml1; Cbfa2; PEA2-alpha; CBF-alpha-2; PEBP2-alpha

Gene ID: 50662 | Gene type: protein coding

About Runx1

Summary

Enables promoter-specific chromatin binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including ovulation; positive regulation of progesterone secretion; and response to denervation involved in regulation of muscle adaptation. Located in chromatin and nucleus. Used to study middle cerebral artery infarction. Biomarker of endometriosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia and esophagus squamous cell carcinoma. Orthologous to human RUNX1 (RUNX family transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Runx1 Products(1)

mRNA Protein Name
NM_017325.2 NP_059021.1 runt-related transcription factor 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
19342459 RGD
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
19342459 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19342459 RGD
involved in positive regulation of progesterone secretion IMP
IMP: Inferred from mutant phenotype
16675540 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21678417 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: Inferred from expression pattern
7969143 RGD
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
21678417 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

runt-related transcription factor 1

PEA2-alpha B

PEBP2-alpha B

acute myeloid leukemia 1 protein

core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene)

core-binding factor subunit alpha-2

oncogene AML-1

polyomavirus enhancer-binding protein 2 alpha B subuni

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19149 Ro24-7429 99.85% Phase 2
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108470 Ro5-3335 Inhibitor 99.52% Unkown
HY-16268 Kartogenin Activator 99.05% Unkown
HY-16786 AI-10-49 Inhibitor 99.24% Unkown
HY-151411 RUNX1/ETO tetramerization-IN-1 Inhibitor 99.88% Unkown
HY-16268A Kartogenin sodium Activator 98.25% Unkown
HY-RS12349 RUNX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12350 RUNX1T1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16650 Runx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118365 NSC 140873 Inhibitor / Unkown
HY-124137 Runx1-CBFβ interaction inhibitor 1 Inhibitor / Unkown
HY-125966 AI-4-57 Inhibitor / Unkown
HY-174367 RUNX1/ETO-IN-1 / Unkown
HY-RS23085 Runx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Runx1 NCBI NCBI:861