PCA3 - prostate cancer associated 3 Gene

Homo sapiens

Also known as DD3; PCAT3; NCRNA00019; PRUNE2-AS1

Gene ID: 50652 | Gene type: ncRNA

About PCA3

Cytogenetic location: 9q21.2 Genomic coordinates (GRCh38): 9:76,764,436-76,787,569 (from NCBI)

This gene has 18 transcripts (splice variants). Restricted expression toward prostate (RPKM 4.9).

Summary

This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate Cancer cells and is used as a specific biomarker for this type of Cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes Adenosine Deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate Cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate Cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

Related Diseases

Diseases

Alias

Prostate Disease

Prostatic Diseases

Prostate Diseases

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Prostatitis

Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia	BPH
Prostatic Hyperplasia

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Prostate Stromal Sarcoma

Stromal Sarcoma Of The Prostate

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