2. Gene
  3. Txnrd1 - thioredoxin reductase 1 Gene

Txnrd1 - thioredoxin reductase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TR; TR1; TrxR1

Gene ID: 50493 | Gene type: protein coding

About Txnrd1

Summary

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as Other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017]

Txnrd1 Products(4)

mRNA Protein Name
NM_001042513.1 NP_001035978.1 thioredoxin reductase 1, cytoplasmic isoform 1
NM_001042514.1 NP_001035979.1 thioredoxin reductase 1, cytoplasmic isoform 1
NM_001042523.1 NP_001035988.1 thioredoxin reductase 1, cytoplasmic isoform 2
NM_015762.2 NP_056577.2 thioredoxin reductase 1, cytoplasmic isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables thioredoxin-disulfide reductase (NADPH) activity IDA
IDA: Inferred from direct assay
11259642 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
15713651 MGI
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
17697936 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
17697936 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10721726 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11259642 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10721726 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin reductase 1, cytoplasmic

TR alpha

peroxidase TXNRD1

thioredoxin reductase TR1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125006 TRi-1 Activator 99.91% Unkown
HY-147328 LCS3 Inducer 99.43% Unkown
HY-RS15298 TXNRD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17152 Txnrd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23602 Txnrd1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Txnrd1 NCBI NCBI:7296