2. Gene
  3. Srf - serum response factor Gene

Srf - serum response factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1559787

Gene ID: 501099 | Gene type: protein coding

About Srf

Summary

Enables histone deacetylase binding activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to glucose stimulus; long-term memory; and positive regulation of transcription by glucose. Located in nucleus. Used to study hepatocellular carcinoma and hypertension. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Apr 2022]

Srf Products(1)

mRNA Protein Name
NM_001109302.2 NP_001102772.1 serum response factor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
12663674 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23110084 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16822834 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20655308 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
15816850 RGD
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16081871 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16081871 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16081871 RGD
involved in positive regulation of transcription by glucose IMP
IMP: Inferred from mutant phenotype
20655308 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serum response factor

serum response factor (c-fos serum response element-binding transcription factor)

Related Agents

Clinical Phase
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P990068 Perenostobart 97.00% Phase 2
HY-P990024 Casdozokitug Inhibitor 96.49% Phase 2
HY-P99533 Urabrelimab Inhibitor 99.47% Phase 1
HY-P991061 CHS-114 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13991 CCG-1423 99.88% Unkown
HY-108361 CCG-203971 Inhibitor 99.89% Unkown
HY-120855 CCG-100602 Inhibitor 99.29% Unkown
HY-111432 CCG-232601 Inhibitor 99.00% Unkown
HY-153078 MRTF/SRF-IN-1 Inhibitor 99.68% Unkown
HY-118748 Suprafenacine Inhibitor ≥98.0% Unkown
HY-162904 BPU17 / Unkown
HY-130011 CCG-232964 Inhibitor / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown
HY-RS13760 SRF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17529 Srf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23985 Srf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srf NCBI NCBI:6722
Mus musculus Srf NCBI NCBI:20807