MEF2C - Mef2c myocyte enhancer factor 2C Gene

Rattus norvegicus

Also known as RGD1563119

Gene ID: 499497 | Gene type: protein coding

About MEF2C

Summary

Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to retinoic acid; dentate gyrus development; and transdifferentiation. Located in nucleus and sarcomere. Used to study myocardial infarction. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Apr 2022]

MEF2C Products(2)

mRNA	Protein	Name
NM_001399397.1	NP_001386326.1	myocyte-specific enhancer factor 2C isoform 1
NM_001399399.1	NP_001386328.1	myocyte-specific enhancer factor 2C isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11782488	RGD
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19654000	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15485823	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	18413674	RGD
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	19654000	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11073966	RGD
involved in cellular response to retinoic acid	IDA IDA: Inferred from direct assay	17568621	RGD
involved in dentate gyrus development	IEP IEP: Inferred from expression pattern	18949272	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	15486975	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	19103177	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19654000	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17696759	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	19103177	RGD
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	19654000	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19654000	RGD
involved in response to ischemia	IDA IDA: Inferred from direct assay	19103177	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	20676734	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	16534476	RGD
involved in transdifferentiation	IMP IMP: Inferred from mutant phenotype	23948075	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19103177	RGD
located in nucleus	IDA IDA: Inferred from direct assay	15862299	RGD
located in sarcomere	IDA IDA: Inferred from direct assay	15862299	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myocyte-specific enhancer factor 2C

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120877	MRT199665		99.74%	Unkown
HY-120877A	(R)-MRT199665		98.70%	Unkown
HY-170237	SIK2/3-IN-1	Inhibitor	/	Unkown
HY-RS08311	MEF2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19021	Mef2c Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25510	Mef2c Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MEF2C	NCBI	NCBI:4208

Name
Email *

	Sorry, but the email address you supplied was invalid.