NKX6-1 - NK6 homeobox 1 Gene

Homo sapiens

Also known as NKX6A; NKX6.1

Gene ID: 4825 | Gene type: protein coding

About NKX6-1

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:84,491,985-84,499,292 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues and 13 paralogues. Biased expression in esophagus (RPKM 3.3), thyroid (RPKM 0.9) and 4 other tissues.

Summary

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]

NKX6-1 Products(1)

mRNA	Protein	Name
NM_006168.3	NP_006159.2	homeobox protein Nkx-6.1

NKX6-1 Protein Structure

Homeobox

0
100
200
300
367 a.a.

Protein Preferred Names

Protein Names

homeobox protein Nkx-6.1

NK homeo box, family 6, member A

NKX6-1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81474	NKX6.1 Antibody (YA1219)	IHC-P	Human

Related Diseases

Diseases

Alias

Pancreatic Agenesis

Partial Pancreatic Agenesis	Congenital Pancreatic Agenesis
Partial Agenesis Of The Pancreas	Agenesis, Pancreatic
Pancreatic Agenesis, Congenital

Maturity-Onset Diabetes Of The Young, Type 4

Maturity-Onset Diabetes Of The Young Type 4	MODY4
Mody, Type Iv	Mody Type 4
Mody, Type 4	Maturity-Onset Diabetes Of The Young 4
Mody-4	Diabetes Of The Young, Maturity-Onset, Type 4
Maturity-Onset Diabetes Of The Young, Type Iv

Neonatal Diabetes

Neonatal Diabetes Mellitus	Diabetes Mellitus Syndrome In Newborn Infant
Ndm

Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3	MODY3
Mody, Type Iii	Mody Type 3
Mody, Type 3	Maturity-Onset Diabetes Of The Young 3
Mody-3	Diabetes Of The Young, Maturity-Onset, Type 3

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Permanent Neonatal Diabetes Mellitus

Pndm	Permanent Diabetes Mellitus Of Infancy
Pdmi	Neonatal Diabetes Mellitus, Permanent

Maturity-Onset Diabetes Of The Young, Type 1

Maturity-Onset Diabetes Of The Young Type 1	MODY1
Mild Juvenile Diabetes Mellitus	Mody, Type I
Diabetes Mellitus Type 2	Mody Type 1
Mody, Type 1	Maturity-Onset Diabetes Of The Young 1
Mody-1	Diabetes Of The Young, Maturity-Onset, Type 1

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09335	NKX6-1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NKX6-1	VGNC	VGNC:78535
Rattus norvegicus	NKX6-1	RGD	RGD:69318
Bos taurus	NKX6-1	VGNC	VGNC:32107
Canis familiaris	NKX6-1	VGNC	VGNC:54334
Macaca mulatta	NKX6-1	VGNC	VGNC:75356
Mus musculus	NKX6-1	MGD	MGI:1206039

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