MYH10 - myosin heavy chain 10 Gene

Homo sapiens

Also known as NMMHCB; NMMHC-IIB

Gene ID: 4628 | Gene type: protein coding

About MYH10

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,474,212-8,631,345 (from NCBI)

This gene has 32 transcripts (splice variants), 212 orthologues, 43 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 33.9), placenta (RPKM 28.3) and 22 other tissues.

Summary

This gene encodes a member of the Myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYH10 Products(4)

mRNA	Protein	Name
NM_001256012.3	NP_001242941.1	myosin-10 isoform 1
NM_001256095.2	NP_001243024.1	myosin-10 isoform 3
NM_001375266.1	NP_001362195.1	myosin-10 isoform 4
NM_005964.5	NP_005955.3	myosin-10 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	15845534	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	15845534	GOA
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	20603131	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	15845534	GOA
contributes to actin filament binding	IMP IMP: Inferred from mutant phenotype	24072716	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	20603131	GOA
enables microfilament motor activity	IDA IDA: Inferred from direct assay	15845534	GOA
contributes to microfilament motor activity	IMP IMP: Inferred from mutant phenotype	24072716	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7542763	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin filament-based movement	IDA IDA: Inferred from direct assay	15845534	GOA
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	24072716	GOA
acts upstream of or within mitotic cytokinesis	IDA IDA: Inferred from direct assay	15774463	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	20603131	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actomyosin	IDA IDA: Inferred from direct assay	24072716	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	7699007	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	7699007	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	7699007	GOA
located in cytosol	IMP IMP: Inferred from mutant phenotype	20603131	GOA
located in midbody	IDA IDA: Inferred from direct assay	11029059	GOA
part of myosin II complex	IDA IDA: Inferred from direct assay	24072716	GOA
located in myosin II filament	IDA IDA: Inferred from direct assay	24072716	GOA
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	30123108	GOA
is active in postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	30123108	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	7699007	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYH10 Protein Structure

Myosin_N

Myosin_head

Myosin_tail_1

0
400
800
1200
1600
1976 a.a.

Protein Preferred Names

Protein Names

myosin-10

myosin heavy chain, nonmuscle type B

MYH10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83369	MYH10 Antibody (YA3114)	WB, IP	Human, Mouse

Related Diseases

Diseases

Alias

Congenital Ptosis

Congenital Blepharoptosis

Congenital Eyelid Ptosis

Coloboma, Ocular, Autosomal Dominant

Coloboma, Ocular	Coloboma Of Iris, Choroid, And Retina
Coi	Coloboma, Uveoretinal
COAD	Ocular Coloboma
Uveoretinal Coloboma	Chronic Obstructive Airway Disease

Coloboma Of Macula

Coloboma	Congenital Ocular Coloboma
Microphthalmia, Isolated, With Coloboma	Agenesis Of Macula
Hereditary Macular Coloboma	Ocular Coloboma
Coloboma Of Eye	Macular Coloboma
Uveoretinal Coloboma

Hypertelorism

Eyes Wide Apart	Eyes Widely Set
Hypertelorism Of Orbit	Ocular Hypertelorism
Orbital Separation Excessive

Myh-9 Related Disease

Myh9-Related Disease	Myh9-Rd
Myh9-Related Disorder	Myh9-Related Syndrome
Myh9-Related Syndromic Thrombocytopenia	Sebastian Syndrome

Lymphangioleiomyomatosis

Lymphangiomyomatosis	LAM
Lung Lymphangioleiomyomatosis	Pulmonary Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, Somatic	Lymphangio-Myomatosis

Deafness, Autosomal Dominant 17

DFNA17	Autosomal Dominant Nonsyndromic Deafness 17
Deafness, Autosomal Dominant Nonsyndromic Sensorineural 17	Autosomal Dominant Deafness 17
Late-Onset Progressive Hereditary Hearing Impairment Due To Cochleosaccular Degeneration	Nonsyndromic Hereditary Deafness Dfna17
Deafness, Autosomal Dominant, 17	Cochleosaccular Degeneration
Deafness, Autosomal Dominant, Type 17	Cochleosaccular Degeneration Of The Inner Ear And Progressive Cataracts

Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08896	MYH10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MYH10	VGNC	VGNC:43535
Felis catus	MYH10	VGNC	VGNC:68379
Bos taurus	MYH10	VGNC	VGNC:31794
Rattus norvegicus	MYH10	RGD	RGD:71000
Macaca mulatta	MYH10	VGNC	VGNC:99175
Mus musculus	MYH10	MGD	MGI:1930780

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