2. Gene
  3. Nlrc5 - NLR family, CARD domain containing 5 Gene

Nlrc5 - NLR family, CARD domain containing 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NOD27

Gene ID: 434341 | Gene type: protein coding

About Nlrc5

Summary

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in innate immune response; negative regulation of NF-kappaB transcription factor activity; and negative regulation of type I interferon-mediated signaling pathway. Acts upstream of or within response to bacterium. Located in cytosol and nucleus. Is expressed in liver. Orthologous to human NLRC5 (NLR family CARD domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Nlrc5 Products(1)

mRNA Protein Name
NM_001033207.3 NP_001028379.2 protein NLRC5
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
20434986 MGI
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
20434986 MGI
involved in negative regulation of type I interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
20434986 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
20639463 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20639463 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein NLRC5

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09348 NLRC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19724 Nlrc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26220 Nlrc5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlrc5 NCBI NCBI:84166