Otulin - OTU deubiquitinase with linear linkage specificity Gene

Mus musculus

Also known as m3Sapc; Fam105b; m7-1Sapc

Gene ID: 432940 | Gene type: protein coding

About Otulin

Summary

Enables thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Located in cytoplasm. Part of LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to human OTULIN (OTU Deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Apr 2022]

Otulin Products(1)

mRNA	Protein	Name
NM_001013792.2	NP_001013814.2	ubiquitin thioesterase otulin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	23708998	MGI
enables cysteine-type peptidase activity	IMP IMP: Inferred from mutant phenotype	23708998	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	27523608	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	27523608	MGI
involved in protein linear deubiquitination	IDA IDA: Inferred from direct assay	23708998	MGI
involved in regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	23708998	MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27523608	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	23708998	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of LUBAC complex	IDA IDA: Inferred from direct assay	23708998	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	23708998	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin thioesterase otulin

OTU domain-containing deubiquitinase with linear linkage specificity	deubiquitinating enzyme otulin
family with sequence similarity 105, member B	gumby
protein FAM105B	ubiquitin thioesterase Gumby

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09878	OTULIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19070	Otulin Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25560	Otulin Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Otulin	NCBI	NCBI:90268

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