2. Gene
  3. Adcy1 - adenylate cyclase 1 Gene

Adcy1 - adenylate cyclase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AC1; brl; I-AC; D11Bwg1392e

Gene ID: 432530 | Gene type: protein coding

About Adcy1

Summary

Enables Adenylate Cyclase activity. Involved in several processes, including modulation of chemical synaptic transmission; neuroinflammatory response; and positive regulation of CREB transcription factor activity. Acts upstream of or within axonogenesis and long-term memory. Located in cytoplasm; glutamatergic synapse; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (Adenylate Cyclase 1). [provided by Alliance of Genome Resources, Apr 2022]

Adcy1 Products(1)

mRNA Protein Name
NM_009622.2 NP_033752.1 adenylate cyclase type 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables adenylate cyclase activity IGI
IGI: Inferred from genetic interaction
10482244 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
17229090 MGI
acts upstream of or within long-term memory IGI
IGI: Inferred from genetic interaction
10482244 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
10482244 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10482244 MGI
involved in neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
12441059 MGI
involved in positive regulation of CREB transcription factor activity IMP
IMP: Inferred from mutant phenotype
12441059 MGI
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
10482244 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
9547227 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
9547227 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
24048828 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
10482244 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
10482244 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24482543 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9547227 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
9547227 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
9547227 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
9547227 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
18448650 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
17335981 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
17335981 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylate cyclase type 1

ATP pyrophosphate-lyase 1

Ca(2+)/calmodulin-activated adenylyl cyclase

adenylate cyclase type I

adenylyl cyclase 1

barrelless

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00326 ADCY1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21473 Adcy1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adcy1 NCBI NCBI:107