Irs2 - insulin receptor substrate 2 Gene

Mus musculus

Also known as Irs-2

Gene ID: 384783 | Gene type: protein coding

About Irs2

Summary

Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of B cell apoptotic process; positive regulation of B cell proliferation; and positive regulation of Insulin secretion. Acts upstream of or within several processes, including animal organ development; Insulin Receptor signaling pathway; and positive regulation of mesenchymal cell proliferation. Located in cytosol and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including brain ventricular layer; hindlimb digit skin; jaw; metanephros; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (Insulin Receptor substrate 2). [provided by Alliance of Genome Resources, Apr 2022]

Irs2 Products(1)

mRNA	Protein	Name
NM_001081212.2	NP_001074681.1	insulin receptor substrate 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol 3-kinase activator activity	IMP IMP: Inferred from mutant phenotype	11375348	MGI
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	11375348	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9813005	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	14733908	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	7534300	MGI
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA IDA: Inferred from direct assay	7534300	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12904469	MGI
acts upstream of cell migration	IGI IGI: Inferred from genetic interaction	17662267	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12904469	MGI
acts upstream of or within cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	11375348	MGI
acts upstream of epithelial cell migration	IGI IGI: Inferred from genetic interaction	17662267	MGI
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	9813005	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	7534300	MGI
acts upstream of or within insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12488434	MGI
acts upstream of or within mammary gland development	IGI IGI: Inferred from genetic interaction	17662267	MGI
involved in negative regulation of B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15572028	MGI
involved in negative regulation of kinase activity	IMP IMP: Inferred from mutant phenotype	19523444	MGI
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	15572028	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12904469	MGI
acts upstream of or within positive regulation of epithelial cell migration	IGI IGI: Inferred from genetic interaction	17662267	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	15572028	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	17662267	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	11375348	MGI
acts upstream of or within positive regulation of type B pancreatic cell proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI
involved in response to glucose	IDA IDA: Inferred from direct assay	15572028	MGI
acts upstream of type B pancreatic cell proliferation	IGI IGI: Inferred from genetic interaction	17636024	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17636024	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11375348	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin receptor substrate 2

4PS

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0119	Lixisenatide	Agonist	99.93%	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170994	I2-IRs ligand-1	Ligand	/	Unkown
HY-RS06918	IRS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P0119S	Lixisenatide (Leu-13C6,15N) TFA		/	Unkown
HY-RS19342	Irs2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25833	Irs2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irs2	NCBI	NCBI:8660

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