2. Gene
  3. Fndc5 - fibronectin type III domain containing 5 Gene

Fndc5 - fibronectin type III domain containing 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PeP; Pxp; 1500001L03Rik

Gene ID: 384061 | Gene type: protein coding

About Fndc5

Summary

This gene encodes a type I transmembrane protein containing fibronectin type III repeat. The encoded transmembrane protein undergoes proteolytic processing to generate a soluble hormone named irisin that is secreted into the bloodstream. The expression of this gene followed by the secretion of irisin from skeletal muscle is induced by exercise. The ectopic expression of the encoded protein in mice causes an elevation of irisin in blood and improves metabolic health. [provided by RefSeq, Jul 2016]

Fndc5 Products(1)

mRNA Protein Name
NM_027402.4 NP_081678.1 fibronectin type III domain-containing protein 5 preproprotein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of brown fat cell differentiation IDA
IDA: Inferred from direct assay
22237023 MGI
involved in response to muscle activity IDA
IDA: Inferred from direct assay
22237023 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12384288 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
22237023 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12384288 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibronectin type III domain-containing protein 5

fibronectin type III repeat-containing protein 2

peroxisomal protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05022 FNDC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17253 Fndc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23707 Fndc5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fndc5 NCBI NCBI:252995
Rattus norvegicus Fndc5 NCBI NCBI:260327