Rrm2b - ribonucleotide reductase M2 B (TP53 inducible) Gene

Mus musculus

Also known as p53R2

Gene ID: 382985 | Gene type: protein coding

About Rrm2b

Summary

Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Acts upstream of or within several processes, including mitochondrial DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Apr 2022]

Rrm2b Products(3)

mRNA	Protein	Name
NM_001357022.1	NP_001343951.1	ribonucleoside-diphosphate reductase subunit M2 B isoform 2
NM_001357023.1	NP_001343952.1	ribonucleoside-diphosphate reductase subunit M2 B isoform 3
NM_199476.1	NP_955770.1	ribonucleoside-diphosphate reductase subunit M2 B isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA IDA: Inferred from direct assay	11517226	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA repair	IMP IMP: Inferred from mutant phenotype	12858174	MGI
acts upstream of or within deoxyribonucleoside triphosphate metabolic process	IMP IMP: Inferred from mutant phenotype	12858174	MGI
acts upstream of or within deoxyribonucleotide biosynthetic process	IDA IDA: Inferred from direct assay	11517226	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	12858174	MGI
acts upstream of or within mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	17486094	MGI
involved in mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	17486094	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	12858174	MGI
involved in positive regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	11517226	MGI
acts upstream of or within renal system process	IMP IMP: Inferred from mutant phenotype	12858174	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	12858174	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ribonucleoside-diphosphate reductase subunit M2 B

TP53-inducible ribonucleotide reductase M2 B

p53-inducible ribonucleotide reductase small subunit 2-like protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12287	RRM2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21746	Rrm2b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rrm2b	NCBI	NCBI:50484

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