Atp2b4 - ATPase, Ca++ transporting, plasma membrane 4 Gene

Mus musculus

Also known as Pmca4

Gene ID: 381290 | Gene type: protein coding

About Atp2b4

Summary

Enables scaffold protein binding activity and Sodium Channel regulator activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of cardiac muscle hypertrophy in response to stress. Located in T-tubule and sperm flagellum. Part of protein-containing complex. Is expressed in several structures, including bladder; heart; intestine wall; liver; and nervous system. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b4 Products(2)

mRNA	Protein	Name
NM_001167949.2	NP_001161421.1	plasma membrane calcium-transporting ATPase 4 isoform a
NM_213616.4	NP_998781.1	plasma membrane calcium-transporting ATPase 4 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28827723	MGI
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	18591664	MGI
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	18591664	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to acetylcholine	IMP IMP: Inferred from mutant phenotype	16956963	MGI
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	15078889	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	15078889	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	25147342	MGI
involved in negative regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	25147342	MGI
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	25147342	MGI
involved in negative regulation of cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	19287093	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25147342	MGI
involved in urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	16956963	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	19287093	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	18591664	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	19287093	MGI
located in sperm flagellum	IDA IDA: Inferred from direct assay	15078889	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plasma membrane calcium-transporting ATPase 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01197	ATP2B4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20525	Atp2b4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27034	Atp2b4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp2b4	NCBI	NCBI:493

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