2. Gene
  3. Parl - presenilin associated, rhomboid-like Gene

Parl - presenilin associated, rhomboid-like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Psarl; PSARL1; PRO2207; PSENIP2; D16Ertd607e

Gene ID: 381038 | Gene type: protein coding

About Parl

Summary

Enables endopeptidase activity. Involved in several processes, including mitochondrial fusion; negative regulation of apoptotic signaling pathway; and regulation of Autophagy of mitochondrion. Located in mitochondrial inner membrane. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Apr 2022]

Parl Products(2)

mRNA Protein Name
NM_001005767.4 NP_001005767.1 presenilins-associated rhomboid-like protein, mitochondrial precursor
NM_001005767.4 NP_001005767.1 presenilins-associated rhomboid-like protein, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21138942 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18288109 MGI
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
16713954 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16839884 MGI
involved in negative regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
16839884 MGI
involved in proteolysis IGI
IGI: Inferred from genetic interaction
21426348 MGI
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
21138942 MGI
involved in regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
21355049 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IMP
IMP: Inferred from mutant phenotype
16839884 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

presenilins-associated rhomboid-like protein, mitochondrial

mitochondrial intramembrane-cleaving protease PARL

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-152265A PARL-IN-1 TFA Activator / Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-152265 PARL-IN-1 Activator / Unkown
HY-169380 PARL-IN-2 / Unkown
HY-RS10044 PARL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18365 Parl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24844 Parl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parl NCBI NCBI:55486