2. Gene
  3. Nlrp12 - NLR family, pyrin domain containing 12 Gene

Nlrp12 - NLR family, pyrin domain containing 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nalp12; PYPAF7; monarch-1

Gene ID: 378425 | Gene type: protein coding

About Nlrp12

Summary

Predicted to enable ATP binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within cellular response to cytokine stimulus; dendritic cell migration; and negative regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp12 Products(1)

mRNA Protein Name
NM_001033431.1 NP_001028603.1 NACHT, LRR and PYD domains-containing protein 12
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22503542 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
22503542 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22503542 MGI
acts upstream of or within cellular response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
20861349 MGI
acts upstream of or within dendritic cell migration IMP
IMP: Inferred from mutant phenotype
20861349 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22503542 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
30212649 MGI
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22503542 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 12

PYRIN-containing APAF1-like protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09352 NLRP12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21166 Nlrp12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27682 Nlrp12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlrp12 NCBI NCBI:91662