Runx2 - RUNX family transcription factor 2 Gene

Rattus norvegicus

Also known as Cbfa1; OSF-2; CBF-alpha-1

Gene ID: 367218 | Gene type: protein coding

About Runx2

Summary

Enables DNA-binding transcription factor binding activity; general transcription initiation factor binding activity; and histone deacetylase binding activity. Involved in cellular response to Fibroblast Growth Factor stimulus; osteoblast differentiation; and positive regulation of ossification. Located in nucleus. Human ortholog(s) of this gene implicated in cleidocranial dysplasia and metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Runx2 Products(2)

mRNA	Protein	Name
NM_001278483.1	NP_001265412.1	runt-related transcription factor 2 isoform 1
NM_001278484.2	NP_001265413.1	runt-related transcription factor 2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18171674	RGD
enables general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	18171674	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	20097749	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17251981	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	12403780	RGD
involved in cellular response to zinc ion starvation	IEP IEP: Inferred from expression pattern	21893222	RGD
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19940863	RGD
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	11784711	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	20818503	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20818503	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

runt-related transcription factor 2

core-binding factor subunit alpha-1

osteoblast-specific transcription factor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107245	Segetalin B	Activator	99.51%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Runx2	NCBI	NCBI:860

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