2. Gene
  3. Smad6 - SMAD family member 6 Gene

Smad6 - SMAD family member 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 367100 | Gene type: protein coding

About Smad6

Summary

Predicted to enable several functions, including SMAD binding activity; signaling receptor binding activity; and transcription regulator inhibitor activity. Involved in response to estrogen. Predicted to be located in Golgi apparatus; cytosol; and nuclear body. Predicted to be part of heteromeric SMAD protein complex. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis. Orthologous to human SMAD6 (Smad Family member 6). [provided by Alliance of Genome Resources, Apr 2022]

Smad6 Products(1)

mRNA Protein Name
NM_001109002.3 NP_001102472.2 mothers against decapentaplegic homolog 6
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in response to estrogen IEP
IEP: Inferred from expression pattern
10363999 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 6

MAD homolog 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13397 SMAD6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18407 Smad6 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24888 Smad6 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad6 NCBI NCBI:4091