2. Gene
  3. Flrt3 - fibronectin leucine rich transmembrane protein 3 Gene

Flrt3 - fibronectin leucine rich transmembrane protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1566005

Gene ID: 366205 | Gene type: protein coding

About Flrt3

Summary

Predicted to enable chemorepellent activity; Fibroblast Growth Factor receptor binding activity; and protein homodimerization activity. Involved in neuron projection extension; response to axon injury; and synapse organization. Acts upstream of or within axon guidance. Located in axon terminus; postsynaptic density; and synaptic membrane. Is integral component of postsynaptic membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Flrt3 Products(1)

mRNA Protein Name
NM_001126291.1 NP_001119763.1 leucine-rich repeat transmembrane protein FLRT3 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
21673655 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
15485775 RGD
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
15485775 RGD
involved in response to axon injury IMP
IMP: Inferred from mutant phenotype
15485775 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon terminus IDA
IDA: Inferred from direct assay
15485775 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15485775 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
15485775 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane protein FLRT3

fibronectin-like domain-containing leucine-rich transmembrane protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04986 FLRT3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20409 Flrt3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26918 Flrt3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flrt3 NCBI NCBI:23767