2. Gene
  3. SPI1 - Spi1 Spi-1 proto-oncogene Gene

SPI1 - Spi1 Spi-1 proto-oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pu.1; Sfpi1

Gene ID: 366126 | Gene type: protein coding

About SPI1

Summary

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in cellular response to ethanol; negative regulation of transcription, DNA-templated; and positive regulation of transcription, DNA-templated. Located in nucleus. Used to study alcohol use disorder. Biomarker of alcohol use disorder. Orthologous to human SPI1 (Spi-1 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

SPI1 Products(1)

mRNA Protein Name
NM_001005892.2 NP_001005892.1 transcription factor PU.1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10867017 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15688197 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10867017 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
16272341 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10867017 RGD
involved in osteoclast differentiation IEP
IEP: Inferred from expression pattern
22576626 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10085160 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
22576626 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor PU.1

SFFV proviral integration 1

hematopoietic transcription factor PU.1

spleen focus forming virus (SFFV) proviral integration oncogene spi1

spleen focus forming virus proviral integration oncogene spi1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13671 SPI1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17194 Spi1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23630 Serpina1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23645 Spi1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SPI1 NCBI NCBI:6688
Mus musculus SPI1 NCBI NCBI:20375