Ncf2 - neutrophil cytosolic factor 2 Gene

Rattus norvegicus

Also known as NCF-2

Gene ID: 364018 | Gene type: protein coding

About Ncf2

Summary

Predicted to enable protein C-terminus binding activity; small GTPase binding activity; and superoxide-generating NADPH Oxidase activator activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Located in cytoplasm and membrane. Used to study proteinuria; renal fibrosis; and visual epilepsy. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease cytochrome b-positive type II; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ncf2 Products(1)

mRNA	Protein	Name
NM_001395185.1	NP_001382114.1	neutrophil cytosol factor 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hormone stimulus	IDA IDA: Inferred from direct assay	18298462	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19307699	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18675340	RGD
involved in regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	27279484	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	17310390	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	19854265	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19337906	RGD
involved in response to laminar fluid shear stress	IEP IEP: Inferred from expression pattern	19353375	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	19713964	RGD
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	17448908	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	19854265	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	19841131	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17122189	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neutrophil cytosol factor 2

neutrophil NADPH oxidase factor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09078	NCF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19358	Ncf2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25849	Ncf2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncf2	NCBI	NCBI:4688

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