2. Gene
  3. Cyp46a1 - cytochrome P450, family 46, subfamily a, polypeptide 1 Gene

Cyp46a1 - cytochrome P450, family 46, subfamily a, polypeptide 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 362782 | Gene type: protein coding

About Cyp46a1

Summary

Predicted to enable Cholesterol 24-hydroxylase activity; heme binding activity; and steroid hydroxylase activity. Predicted to be involved in several processes, including Cholesterol catabolic process; progesterone metabolic process; and regulation of long-term synaptic potentiation. Predicted to act upstream of with a negative effect on protein localization to membrane raft. Predicted to be located in several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (Cytochrome P450 family 46 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp46a1 Products(1)

mRNA Protein Name
NM_001399701.1 NP_001386630.1 cholesterol 24-hydroxylase precursor
Protein Preferred Names Protein Names

cholesterol 24-hydroxylase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109123 Soticlestat Inhibitor 99.83% Phase 3
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-144309 Cholesterol 24-hydroxylase-IN-1 Inhibitor 99.53% Unkown
HY-156799 Cholesterol 24-hydroxylase-IN-2 Inhibitor / Unkown
HY-172205 CHL2310 Inhibitor / Unkown
HY-E70510 Human CYP46A1,Low-Reductase / Unkown
HY-E70511 Human CYP46A1,High-Reductase / Unkown
HY-RS03475 CYP46A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18437 Cyp46a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24919 Cyp46a1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp46a1 NCBI NCBI:10858