Macf1 - microtubule-actin crosslinking factor 1 Gene

Rattus norvegicus

Gene ID: 362587 | Gene type: protein coding

About Macf1

Summary

Predicted to enable actin filament binding activity; microtubule minus-end binding activity; and structural molecule activity. Involved in positive regulation of Wnt signaling pathway. Located in membrane. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Macf1 Products(1)

mRNA	Protein	Name
NM_001135758.3	NP_001129230.2	microtubule-actin cross-linking factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16815997	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16815997	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	16815997	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microtubule-actin cross-linking factor 1

actin cross-linking family 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07942	MACF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22621	Macf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS29136	Macf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Macf1	NCBI	NCBI:23499

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