Ank3 - ankyrin 3 Gene

Rattus norvegicus

Also known as ANK-3

Gene ID: 361833 | Gene type: protein coding

About Ank3

Summary

Enables several functions, including Cadherin binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in several processes, including clustering of voltage-gated sodium channels; positive regulation of protein targeting to membrane; and regulation of ion transport. Located in several cellular components, including Z disc; main axon; and spectrin-associated Cytoskeleton. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ANK3 (ankyrin 3). [provided by Alliance of Genome Resources, Apr 2022]

Ank3 Products(2)

mRNA	Protein	Name
NM_001033984.1	NP_001029156.1	ankyrin-3 isoform 2
NM_031805.2	NP_113993.1	ankyrin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadherin binding	IPI IPI: Inferred from physical interaction	17620337	RGD
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	21223964	RGD
enables phosphorylation-dependent protein binding	IPI IPI: Inferred from physical interaction	25950943	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12805291	RGD
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	17620337	RGD
enables spectrin binding	IDA IDA: Inferred from direct assay	17620337	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	15579534	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde axonal transport	IMP IMP: Inferred from mutant phenotype	31474508	RGD
involved in axon development	IMP IMP: Inferred from mutant phenotype	27098687	RGD
involved in clustering of voltage-gated sodium channels	IMP IMP: Inferred from mutant phenotype	17709431	RGD
involved in establishment or maintenance of microtubule cytoskeleton polarity	IMP IMP: Inferred from mutant phenotype	27098687	RGD
involved in maintenance of protein location in cell	IMP IMP: Inferred from mutant phenotype	27098687	RGD
involved in membrane assembly	IGI IGI: Inferred from genetic interaction	14757759	RGD
involved in negative regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	31474508	RGD
involved in neuromuscular junction development	IEP IEP: Inferred from expression pattern	12657669	RGD
involved in positive regulation of cation channel activity	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in positive regulation of cell communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	21617128	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in positive regulation of homotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	21617128	RGD
involved in positive regulation of membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in positive regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	29079505	RGD
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in positive regulation of sodium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	21617128	RGD
involved in positive regulation of sodium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in protein localization to axon	IMP IMP: Inferred from mutant phenotype	25950943	RGD
involved in protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	14757759	RGD
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	18180363	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	25374361	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	25374361	RGD
involved in regulation of potassium ion transport	IDA IDA: Inferred from direct assay	16525039	RGD
involved in regulation of protein targeting	IMP IMP: Inferred from mutant phenotype	18094255	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	27824361	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	15579534	RGD
located in Z disc	IDA IDA: Inferred from direct assay	9664041	RGD
located in axon	IDA IDA: Inferred from direct assay	17709431	RGD
located in axon initial segment	IDA IDA: Inferred from direct assay	11724816	RGD
located in axon initial segment	IMP IMP: Inferred from mutant phenotype	25950943	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21223964	RGD
located in costamere	IDA IDA: Inferred from direct assay	11171381	RGD
located in dendrite	IDA IDA: Inferred from direct assay	18786578	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25374361	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25374361	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	15579534	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	12657669	RGD
located in node of Ranvier	IDA IDA: Inferred from direct assay	17548513	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16525039	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	25374361	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	25374361	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	9664041	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	11796721	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	9664041	RGD
located in spectrin-associated cytoskeleton	IDA IDA: Inferred from direct assay	17620337	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ankyrin-3

ankyrin 3 (G)	ankyrin 3, epithelial
ankyrin 3, node of Ranvier (ankyrin G)	ankyrin-G

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00701	ANK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19574	Ank3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26071	Ank3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ank3	NCBI	NCBI:288

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