2. Gene
  3. SMARCB1 - Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Gene

SMARCB1 - Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361825 | Gene type: protein coding

About SMARCB1

Summary

Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including nucleosome disassembly; regulation of histone modification; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including blastocyst hatching; negative regulation of cell population proliferation; and single stranded viral RNA replication via double stranded DNA intermediate. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; neurilemmomatosis; and rhabdoid Cancer. Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Apr 2022]

SMARCB1 Products(1)

mRNA Protein Name
NM_001025728.1 NP_001020899.1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
8895581 RGD
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
29398003 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13803 Tazemetostat 99.93% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145925B CFT8634 Inhibitor 98.10% Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131246 DM-01 Inhibitor 98.03% Unkown
HY-RS13409 SMARCB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17520 Smarcb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23976 Smarcb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SMARCB1 NCBI NCBI:6598