2. Gene
  3. Il33 - interleukin 33 Gene

Il33 - interleukin 33 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1311155

Gene ID: 361749 | Gene type: protein coding

About Il33

Summary

Predicted to enable cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of oligodendrocyte differentiation; and regulation of sensory perception of pain. Located in nucleus. Biomarker of acute myocardial infarction; colon cancer; and diabetes mellitus. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Apr 2022]

Il33 Products(1)

mRNA Protein Name
NM_001014166.1 NP_001014188.1 interleukin-33
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17492053 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17492053 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
31165473 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-33

IL-33

Related Agents

Clinical Phase
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99444 Astegolimab Inhibitor 99.00% Phase 3
HY-P99673 Itepekimab Inhibitor 99.40% Phase 3
HY-P99018 Etokimab Inhibitor 99.90% Phase 2
HY-P99729 Melrilimab Inhibitor 96.07% Phase 2
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P2729 Subtilisin Activator / Unkown
HY-168532 ST2-IN-1 Inhibitor / Unkown
HY-163140 IL-33 probe-1 / Unkown
HY-RS06757 IL33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16666 Il33 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23101 Il33 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990669 Torudokimab Inhibitor 99.72% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il33 NCBI NCBI:90865
Macaca fascicularis Il33 NCBI NCBI:102140695
Mus musculus Il33 NCBI NCBI:77125
Macaca mulatta Il33 NCBI NCBI:717301