2. Gene
  3. UBE3A - Ube3a ubiquitin protein ligase E3A Gene

UBE3A - Ube3a ubiquitin protein ligase E3A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361585 | Gene type: protein coding

About UBE3A

Summary

Predicted to enable transcription coactivator activity and ubiquitin protein Ligase activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; locomotory exploration behavior; and motor learning. Predicted to be located in cytosol and nucleus. Predicted to be part of Proteasome complex. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein Ligase E3A). [provided by Alliance of Genome Resources, Apr 2022]

UBE3A Products(1)

mRNA Protein Name
NM_001191837.4 NP_001178766.1 ubiquitin-protein ligase E3A
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
25867122 RGD
involved in locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
32066685 RGD
involved in motor learning IMP
IMP: Inferred from mutant phenotype
32066685 RGD
involved in negative regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25867122 RGD
involved in positive regulation of Golgi lumen acidification IMP
IMP: Inferred from mutant phenotype
23447592 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
24810662 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17883392 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-protein ligase E3A

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148130 Rugonersen Activator 91.12% Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148130A Rugonersen sodium 91.12% Unkown
HY-162683 (S)-PHA533533 Inhibitor 98.27% Unkown
HY-RS15368 UBE3A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20508 Ube3a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27016 Ube3a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens UBE3A NCBI NCBI:7337