2. Gene
  3. Top2b - DNA topoisomerase II beta Gene

Top2b - DNA topoisomerase II beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361100 | Gene type: protein coding

About Top2b

Summary

Enables ribonucleoprotein complex binding activity. Involved in several processes, including cellular response to ATP; cellular response to hydrogen peroxide; and positive regulation of double-strand break repair via nonhomologous end joining. Located in nucleolus. Orthologous to human TOP2B (DNA Topoisomerase II beta). [provided by Alliance of Genome Resources, Apr 2022]

Top2b Products(1)

mRNA Protein Name
NM_001100858.2 NP_001094328.2 DNA topoisomerase 2-beta
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ribonucleoprotein complex binding IPI
IPI: Inferred from physical interaction
20554522 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to ATP IDA
IDA: Inferred from direct assay
25034690 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
22019940 RGD
involved in cellular senescence IEP
IEP: Inferred from expression pattern
20708677 RGD
involved in positive regulation of double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
22019940 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA topoisomerase 2-beta

topoisomerase (DNA) II beta

topoisomerase II beta

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14897 TOP2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123393 PNU-142586 Inhibitor / Unkown
HY-174374 Topobexin Inhibitor / Unkown
HY-RS20119 Top2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26623 Top2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top2b NCBI NCBI:7155