PCK2 - Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) Gene

Rattus norvegicus

Also known as PEPCK-M

Gene ID: 361042 | Gene type: protein coding

About PCK2

Summary

Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including carboxylic acid metabolic process; gluconeogenesis; and positive regulation of Insulin secretion. Located in mitochondrion. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

PCK2 Products(1)

mRNA	Protein	Name
NM_001108377.2	NP_001101847.2	phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoenolpyruvate carboxykinase (GTP) activity	IDA IDA: Inferred from direct assay	6049928	RGD
enables phosphoenolpyruvate carboxykinase activity	IDA IDA: Inferred from direct assay	4353083	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADH oxidation	IDA IDA: Inferred from direct assay	19635791	RGD
involved in NADH oxidation	IMP IMP: Inferred from mutant phenotype	19635791	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	19635791	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	19268478	RGD
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	4353083	RGD
involved in oxaloacetate metabolic process	IDA IDA: Inferred from direct assay	6049928	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	19635791	RGD
involved in pyruvate metabolic process	IMP IMP: Inferred from mutant phenotype	19635791	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	16570165	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19268478	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16227	Pck2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10153	PCK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23789	Pck2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PCK2	NCBI	NCBI:5106

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