2. Gene
  3. OGDH - Ogdh oxoglutarate dehydrogenase Gene

OGDH - Ogdh oxoglutarate dehydrogenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as E1o; OGDH-E1

Gene ID: 360975 | Gene type: protein coding

About OGDH

Summary

Enables chaperone binding activity; heat shock protein binding activity; and oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in several processes, including 2-oxoglutarate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Part of oxoglutarate dehydrogenase complex. Orthologous to human OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

OGDH Products(1)

mRNA Protein Name
NM_001017461.1 NP_001017461.1 2-oxoglutarate dehydrogenase complex component E1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
9811814 RGD
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IDA
IDA: Inferred from direct assay
9712727 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
9811814 RGD
Biological Process GO Annotation Evidence Reference Source
involved in 2-oxoglutarate metabolic process IDA
IDA: Inferred from direct assay
3571202 RGD
involved in NADH metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in succinyl-CoA metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in tricarboxylic acid cycle IDA
IDA: Inferred from direct assay
9712727 RGD
Cellular Component GO Annotation Evidence Reference Source
part of oxoglutarate dehydrogenase complex IDA
IDA: Inferred from direct assay
3571202 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2-oxoglutarate dehydrogenase complex component E1

2-oxoglutarate dehydrogenase, mitochondrial

2-oxoglutarate dehydrogenase E1 component, mitochondrial

2-oxoglutarate dehydrogenase, mitochondrial-like

OGDC-E1

alpha-KGDH-E1

alpha-ketoglutarate dehydrogenase

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

oxoglutarate dehydrogenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12688A Succinyl phosphonate trisodium salt Inhibitor ≥98.0% Unkown
HY-12688 Succinyl phosphonate Inhibitor / Unkown
HY-RS17494 Ogdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09758 OGDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23951 Ogdh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens OGDH NCBI NCBI:4967
Mus musculus OGDH NCBI NCBI:18293