Ptprf - protein tyrosine phosphatase, receptor type, F Gene

Rattus norvegicus

Also known as LARFN5C

Gene ID: 360406 | Gene type: protein coding

About Ptprf

Summary

Enables phosphate ion binding activity; signaling receptor binding activity; and transmembrane receptor protein tyrosine Phosphatase activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of signal transduction; and regulation of cell projection organization. Located in several cellular components, including excitatory synapse; growth cone; and neuronal cell body. Is integral component of postsynaptic density membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine Phosphatase receptor type F). [provided by Alliance of Genome Resources, Apr 2022]

Ptprf Products(1)

mRNA	Protein	Name
NM_019249.2	NP_062122.2	receptor-type tyrosine-protein phosphatase F precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables insulin receptor binding	IDA IDA: Inferred from direct assay	7711057	RGD
enables phosphate ion binding	IDA IDA: Inferred from direct assay	1918076	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12629171	RGD
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	8068021	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16415345	RGD
enables transmembrane receptor protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	7711057	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	12716943	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16415345	RGD
involved in negative regulation of cell projection organization	IMP IMP: Inferred from mutant phenotype	10699984	RGD
involved in negative regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16415345	RGD
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8557682	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8557682	RGD
involved in negative regulation of neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10699984	RGD
involved in nervous system development	IDA IDA: Inferred from direct assay	12716943	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9501065	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	15750591	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10699984	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	7711057	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	15750591	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	15750591	RGD
involved in regulation of synapse structure or activity	IMP IMP: Inferred from mutant phenotype	15750591	RGD
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	20139422	RGD
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	20139422	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	16269466	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	15750591	RGD
located in growth cone	IDA IDA: Inferred from direct assay	9604206	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9748473	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	15750591	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase F

LAR	leukocyte antigen-related (LAR) PTP receptor
leukocyte common antigen related

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11438	PTPRF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17614	Ptprf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24074	Ptprf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptprf	NCBI	NCBI:5792

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