IL12RB1 - interleukin 12 receptor subunit beta 1 Gene

Homo sapiens

Also known as CD212; IMD30; IL12RB; IL-12R-BETA1

Gene ID: 3594 | Gene type: protein coding

About IL12RB1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,058,995-18,098,816 (from NCBI)

This gene has 7 transcripts (splice variants), 506 orthologues, 23 paralogues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 5.0), spleen (RPKM 4.1) and 13 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

IL12RB1 Products(4)

mRNA	Protein	Name
NM_001290023.2	NP_001276952.1	interleukin-12 receptor subunit beta-1 isoform 3 precursor
NM_001290024.1	NP_001276953.1	interleukin-12 receptor subunit beta-1 isoform 4
NM_005535.3	NP_005526.1	interleukin-12 receptor subunit beta-1 isoform 1 precursor
NM_153701.3	NP_714912.1	interleukin-12 receptor subunit beta-1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	29287995	GOA
contributes to interleukin-12 receptor activity	IDA IDA: Inferred from direct assay	8943050	GOA
contributes to interleukin-12 receptor binding	IPI IPI: Inferred from physical interaction	12023369	GOA
contributes to interleukin-23 binding	IPI IPI: Inferred from physical interaction	12023369	GOA
contributes to interleukin-23 receptor activity	IDA IDA: Inferred from direct assay	12023369	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	12023369	GOA
involved in interleukin-12-mediated signaling pathway	IDA IDA: Inferred from direct assay	8943050	GOA
involved in interleukin-23-mediated signaling pathway	IDA IDA: Inferred from direct assay	29287995	GOA
involved in positive regulation of T-helper 1 type immune response	IDA IDA: Inferred from direct assay	15114670	GOA
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	11114383	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	12421946	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	11114383	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	14635048	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of interleukin-12 receptor complex	IDA IDA: Inferred from direct assay	12023369	GOA
part of interleukin-23 receptor complex	IDA IDA: Inferred from direct assay	12023369	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL12RB1 Protein Structure

fn3

0
200
400
600
662 a.a.

Protein Preferred Names

Protein Names

interleukin-12 receptor subunit beta-1

IL-12 receptor beta component

Recombinant IL12RB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70647	IL-12R beta 1 Protein, Human (HEK293, His)	P42701-1 (C24-E540)	≥95%
HY-P78862	IL-12R beta 1 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P42701-1 (C24-E540)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 30

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency	IMD30
Il12rb1 Deficiency	Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency
Msmd Due To Complete Il12rb1 Deficiency	Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency
Il-12râ1 Deficiency	Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency
Immunodeficiency, Type 30

Salmonellosis

Salmonella Infections

Salmonella Infection

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Miliary Tuberculosis

Acute Miliary Tuberculosis	Disseminated Tuberculosis
Tuberculosis, Miliary	Generalized Tuberculosis
Tuberculosis Miliaris Disseminata	Tuberculosis Miliary
Tuberculosis Disseminated	Miliary Tb - [Tuberculosis]
Generalised Tuberculosis	Concato Disease
Diffuse Necrotic Tuberculosis	Diffuse Necrotizing Tuberculosis
Diffuse Tuberculous Degeneration	Diffuse Tuberculous Gangrene
Mtb - [Miliary Tuberculosis]	Miliary Tuberculous
Miliary Tuberculosis Unspecified	Disseminated Miliary Tuberculosis
Disseminated Necrotic Tuberculosis	Disseminated Necrotizing Tuberculosis
Disseminated Tuberculous Gangrene	Disseminated Tuberculous Degeneration

Pulmonary Sarcoidosis

Sarcoidosis, Pulmonary	Lung Sarcoidosis
Sarcoidosis Pulmonary	Lung Sarcoid
Sarcoidosis In Lung

Axillary Adenitis

Axillary Lymphadenitis

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Pulmonary Tuberculosis

Tuberculosis, Pulmonary	PTB
Tuberculosis Pulmonary

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Adenitis	Chronic Adenitis
Acute Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Immunodeficiency 29

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency	IMD29
Il12b Deficiency	Immunodeficiency 29, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency	Msmd Due To Complete Il12b Deficiency
Msmd Due To Complete Interleukin 12b Deficiency	Immunodeficiency, Type 29, Mycobacteriosis

Mycobacterium Fortuitum

Paracoccidioidomycosis

Mucocutaneous-Lymphangitic Paracoccidioidomycosis	Paracoccidioidal Mycosis
Lobo Disease	Lutz-Splendore-Almeida Disease
Pcm	Paracoccidioidal Granuloma
South American Blastomycosis	Lobomycosis
Brazilian Blastomycosis	Lutz Disease
Brazilian Blastomycotic	South American Blastomyces Infection
Paracoccidioides Brasiliensis Infection	Paracoccidioidomycosis Unspecified

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency	IMD35
Tyk2 Deficiency	Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis
Susceptibility To Infection Due To Tyk2 Deficiency	Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive
Hies With Atypical Mycobacteriosis, Autosomal Recessive	Autosomal Recessiv Hies With Atypical Mycobacteriosis
Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency	Autosomal Recessive Hies With Atypical Mycobacteriosis

Nocardiosis

Nocardia Infection	Nocardia Infections
Nocardia Infectious Disease	Lung Nocardiosis
Nocardiasis	Nocardiosis Nos

Opportunistic Bacterial Infectious Disease

Subacute Sclerosing Panencephalitis

SSPE	Dawson Encephalitis
Immunosuppressive Measles Encephalitis	Subacute Sclerosing Leukoencephalitis
Panencephalitis, Subacute Sclerosing	Subacute Sclerosing Leukoencephalopathy
Van Bogaert'S Sclerosing Leukoencephalitis	Dawson Disease
Subacute Inclusion Body Encephalitis	Van Bogaert Disease
Van Bogaert Encephalitis	Measles Inclusion Body Encephalitis
Mibe - [Measles Inclusion Body Encephalitis]	Sspe - [Subacute Sclerosing Panencephalitis]
Van Bogaert Leukoencephalitis	Van Bogaert Sclerosing Leukoencephalitis
Dawson Inclusion Body Encephalitis	Van Bogaert Sclerosing Leukoencephalopathy
Bodechtel Guttman Disease	Diffuse Sclerosing Encephalitis

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Hidradenitis Suppurativa

Acne Inversa	Suppurative Hidradenitis
Acne Inversa, Familial	Apocrinitis
Hidradenitides, Suppurative	Hidradenitis, Suppurative
Suppurative Hidradenitides	Inverse Acne

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Hidradenitis

Hydradenitis

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Myocarditis

Myocardial Inflammation

Inflammatory Cardiomyopathy

Tuberculous Salpingitis

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Tropical Spastic Paraparesis

Tropical Spastic Paraplegia	Ham/Tsp
Htlv-Associated Myelopathy	Tropical Spastic Paralysis
Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis	Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis
Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis	Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis	Tsp
Paraparesis Tropical Spastic	Paraparesis, Tropical Spastic

Immunodeficiency 21

Monocytopenia And Mycobacterial Infection Syndrome	Monomac
Gata2 Deficiency	Monocytopenia With Susceptibility To Infections
Dcml	IMD21
Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency	Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia
Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections	Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections
Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency	Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome
Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia	Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections
Monocyte - B - Natural Killer - Dendritic Cell Deficiency	Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections
Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency	Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia

Primary Systemic Mycosis

Macs Syndrome

Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis	Mycobacterium Avium Complex Disease
Rin2 Syndrome	Mycobacterium Avium-Intracellulare Infection
Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis	Mycobacterium Avium Complex
Mycobacterium Avium Infection	Infection Due To Mycobacterium Intracellulare
Mac Disease	Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome
Rin2 Deficiency	Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome
MACS	Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome

Coccidioidomycosis

Valley Fever	Primary Extrapulmonary Coccidioidomycosis
Coccidioides Immitis Infection	Coccidiosis
Coccidioides Infection	Coccidioidomycosis, Unspecified
San Joaquin Fever	California Disease
Desert Fever	Desert Rheumatism
San Joaquin Valley Fever	Enteric Coccidiosis
Primary Pulmonary Coccidioidomycosis	Acute Coccidioidomycosis
Posadas Wernicke Disease

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency	IMD16
Ox40 Deficiency	Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma
Combined Immunodeficiency With Impaired Immunity To Hhv-8	Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8
Immunodeficiency, Type 16

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Penicilliosis

Cutaneous Candidiasis

Candidiasis, Cutaneous

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome	Hyper-Ige Recurrent Infection Syndrome 1
Hyperimmunoglobulin E Syndrome	Job'S Syndrome
Recurring Cold Staphylococcal Abscesses	Ige Syndromes
Buckley Syndrome	Hie - [Hyperimmunoglobulin E] Syndrome
Job-Buckley Syndrome	Quie-Hill Syndrome

Autoimmune Polyendocrine Syndrome

Autoimmune Polyendocrinopathy	Autoimmune Polyglandular Failure
Autoimmune Polyglandular Syndrome	Polyendocrinopathies, Autoimmune
Lloyd'S Syndrome	Aps
Polyendocrinopathies Autoimmune	Polyendocrine Autoimmunity Syndrome
Lloyd Syndrome	Polyglandular Autoimmune Deficiency
Progressive Pluriglandular Insufficiency	Pluriglandular Autoimmune Atrophy
Pluriglandular Autoimmune Syndrome	Thyroid-Adrenocortical Insufficiency Syndrome

Immunodeficiency 13

Idiopathic Cd4 Lymphopenia	IMD13
Icl	Immunodeficiency, Type 13

Histoplasmosis

Darling Disease	Reticuloendotheliosis, X-Linked
Infection By Histoplasma Capsulatum	Histoplasma Infection
Reticuloendothelial Cytomycosis	Cytomycosis
Darling Histoplasmosis	African Histoplasmosis
Histoplasmosis Duboisii

Oral Candidiasis

Thrush	Candidiasis Of Mouth
Oral Moniliasis	Thrush, Oral
Candidiasis, Oral	Oral Thrush
Candidiasis	Equine Thrush

Dermatophytosis

Tinea	Dermatophytosis, Unspecified
Ringworm	Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton
Cutaneous Mycosis	Dermal Mycosis
Superficial Mycosis, Unspecified	Fungus Infection Of Skin
Skin Mycosis	Dermatitis Fungoid
Fungal Dermatitis	Fungal Dermatosis
Mycotic Infection Of Skin

T Cell And Nk Cell Immunodeficiency

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Extrapulmonary Tuberculosis

EPTB	Tuberculosis, Extrapulmonary

Immunodeficiency 27b

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency	IMD27B
Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant	Ifngr1 Deficiency, Autosomal Dominant
Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27b, Mycobacteriosis, Ad
Autosomal Dominant Ifngr1 Deficiency	Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis
Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Fungal Infectious Disease

Mycoses

Mycosis

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Sweeney-Cox Syndrome

SWCOS

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06683	IL12RB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174616	Human IL23R mRNA		/	Unkown
HY-174640	Human IL12RB1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IL12RB1	VGNC	VGNC:41934
Rattus norvegicus	IL12RB1	RGD	RGD:620025
Bos taurus	IL12RB1	VGNC	VGNC:30112
Mus musculus	IL12RB1	MGD	MGI:104579
Felis catus	IL12RB1	VGNC	VGNC:82440
Macaca mulatta	IL12RB1	VGNC	VGNC:73707
Others	IL12RB1	NCBI