NLRP10 - NLR family pyrin domain containing 10 Gene

Homo sapiens

Also known as NOD8; PAN5; PYNOD; NALP10; CLR11.1

Gene ID: 338322 | Gene type: protein coding

About NLRP10

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,957,537-7,965,447 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 231 orthologues and 20 paralogues. Restricted expression toward skin (RPKM 2.7).

Summary

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, Caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and Apoptosis. [provided by RefSeq, Jul 2008]

NLRP10 Products(2)

mRNA	Protein	Name
NM_001391958.1	NP_001378887.1	NACHT, LRR and PYD domains-containing protein 10
NM_176821.4	NP_789791.1	NACHT, LRR and PYD domains-containing protein 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	23861819	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	23861819	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	22672233	GOA
involved in positive regulation of defense response to bacterium	IMP IMP: Inferred from mutant phenotype	28766990	GOA
involved in positive regulation of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	28766990	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	22672233	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	22672233	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22672233	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	22672233	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRP10 Protein Structure

PYRIN

NACHT

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 10

NACHT, leucine rich repeat and PYD containing 10

Related Diseases

Diseases

Alias

Petrositis

Acute Petrositis	Chronic Petrositis
Inflammation Of Petrous Bone	Osteitis Of Petrous Bone
Osteomyelitis Of Petrous Bone

Neurodevelopmental Disorder With Involuntary Movements

NEDIM

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09350	NLRP10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NLRP10	VGNC	VGNC:81970
Mus musculus	NLRP10	MGD	MGI:2444084
Canis familiaris	NLRP10	VGNC	VGNC:43846
Rattus norvegicus	NLRP10	RGD	RGD:1307387
Macaca mulatta	NLRP10	VGNC	VGNC:110523

Name
Email *

	Sorry, but the email address you supplied was invalid.