2. Gene
  3. Dna2 - DNA replication helicase/nuclease 2 Gene

Dna2 - DNA replication helicase/nuclease 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dna2l; E130315B21Rik

Gene ID: 327762 | Gene type: protein coding

About Dna2

Summary

Enables 5'-flap Endonuclease activity. Involved in mitotic telomere maintenance via semi-conservative replication and nucleic acid phosphodiester bond hydrolysis. Located in chromosome, telomeric region. Human ortholog(s) of this gene implicated in Seckel syndrome 8; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6; isolated growth hormone deficiency type IA; and mitochondrial myopathy. Orthologous to human DNA2 (DNA replication helicase/nuclease 2). [provided by Alliance of Genome Resources, Apr 2022]

Dna2 Products(1)

mRNA Protein Name
NM_177372.3 NP_796346.2 DNA replication ATP-dependent helicase/nuclease DNA2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 5'-flap endonuclease activity IDA
IDA: Inferred from direct assay
23604072 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23604072 MGI
Biological Process GO Annotation Evidence Reference Source
involved in mitotic telomere maintenance via semi-conservative replication IMP
IMP: Inferred from mutant phenotype
23604072 MGI
involved in nucleic acid metabolic process IDA
IDA: Inferred from direct assay
23604072 MGI
involved in telomere maintenance IMP
IMP: Inferred from mutant phenotype
23604072 MGI
Cellular Component GO Annotation Evidence Reference Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
23604072 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA replication ATP-dependent helicase/nuclease DNA2

DNA replication ATP-dependent helicase-like homolog

DNA replication helicase 2 homolog

DNA2-like helicase

Related Agents

Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128729 DNA2 inhibitor C5 Inhibitor 98.51% Unkown
HY-107999 CADD522 Agonist 98.23% Unkown
HY-126861 2'-Deoxy-5-formylcytidine 99.70% Unkown
HY-124838 EG1 98.26% Unkown
HY-W016009 2'-Deoxyadenosine-5'-monophosphate 99.60% Unkown
HY-135009 2-Di-1-ASP 99.97% Unkown
HY-155339 Anticancer agent 168 97.44% Unkown
HY-W105272 2′-Deoxyadenosine 5′-monophosphate disodium 99.68% Unkown
HY-160839 SPB-PEG4-AAD / Unkown
HY-160840 SPB-AAD / Unkown
HY-W016009R 2'-Deoxyadenosine-5'-monophosphate (Standard) / Unkown
HY-W105272S 2′-Deoxyadenosine 5′-monophosphate-13C10,15N5 disodium 99.8% Unkown
HY-RS03838 DNA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W008848S DMT-dG(ib) Phosphoramidite-13C10,15N5 / Unkown
HY-W008848S1 DMT-dG(ib) Phosphoramidite-15N5 / Unkown
HY-W008849S DMT-dC(bz) Phosphoramidite-13C9,15N3 / Unkown
HY-W013059S1 DMT-dA(bz) Phosphoramidite-15N5 / Unkown
HY-W013068S1 DMT-dT Phosphoramidite-15N2 / Unkown
HY-W016009S 2'-Deoxyadenosine-5'-monophosphate-d12 dilithium / Unkown
HY-W016009S1 2'-Deoxyadenosine-5'-monophosphate-15N5,d12 dilithium / Unkown
HY-W016009S2 2'-Deoxyadenosine-5'-monophosphate-15N5 dilithium / Unkown
HY-W016009S3 2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium / Unkown
HY-W016009S4 2'-Deoxyadenosine-5'-monophosphate-13C10,15N5 dilithium / Unkown
HY-RS19320 Dna2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25811 Dna2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W013059S DMT-dA(bz) Phosphoramidite-13C10,15N5 / Unkown
HY-W013068S DMT-dT Phosphoramidite-13C10,15N2 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dna2 NCBI NCBI:1763