2. Gene
  3. Lefty2 - left-right determination factor 2 Gene

Lefty2 - left-right determination factor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ebaf; Lefta; Leftb; lefty-2; lefty-B; 6030463A22Rik

Gene ID: 320202 | Gene type: protein coding

About Lefty2

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This protein is also important in self-renewal and differentiation of mouse embryonic stem cells. Mice lacking a functional copy of this gene exhibit defects in axial and left-right patterning. [provided by RefSeq, Aug 2016]

Lefty2 Products(1)

mRNA Protein Name
NM_177099.4 NP_796073.1 left-right determination factor 2 preproprotein
Protein Preferred Names Protein Names

left-right determination factor 2

endometrial bleeding associated factor

left-right determination factor B

left-right determination, factor A

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07586 LEFTY2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18868 Lefty2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25359 Lefty2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lefty2 NCBI NCBI:7044