Rc3h2 - ring finger and CCCH-type zinc finger domains 2 Gene

Mus musculus

Also known as Mnab; Rnf164; 2900024N03Rik; 9430019J22Rik; D930043C02Rik

Gene ID: 319817 | Gene type: protein coding

About Rc3h2

Summary

Enables mRNA binding activity. Involved in T cell receptor signaling pathway; negative regulation of T-helper 17 cell differentiation; and regulation of miRNA metabolic process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Predicted to be located in cell surface; intracellular membrane-bounded organelle; and membrane. Predicted to be active in cytoplasmic stress granule. Orthologous to human RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Apr 2022]

Rc3h2 Products(2)

mRNA	Protein	Name
NM_001100591.1	NP_001094061.1	roquin-2 isoform a
NM_001290642.1	NP_001277571.1	roquin-2 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	23583643	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23583643	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IGI IGI: Inferred from genetic interaction	23583643	MGI
acts upstream of or within T cell homeostasis	IGI IGI: Inferred from genetic interaction	23583643	MGI
acts upstream of or within T cell proliferation	IGI IGI: Inferred from genetic interaction	23583643	MGI
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25282160	MGI
acts upstream of or within T follicular helper cell differentiation	IGI IGI: Inferred from genetic interaction	23583643	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	23583643	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	23583643	MGI
acts upstream of or within lymph node development	IGI IGI: Inferred from genetic interaction	23583643	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	23583643	MGI
involved in negative regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	25282160	MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23583643	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	23583643	MGI
acts upstream of or within post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	23583643	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	23583643	MGI
involved in regulation of miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	25697406	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	23583643	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

roquin-2

RING-type E3 ubiquitin transferase Roquin-2	membrane associated DNA binding protein
membrane-associated nucleic acid binding protein	ring finger and CCCH-type zinc finger domain-containing protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11778	RC3H2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21727	Rc3h2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rc3h2	NCBI	NCBI:54542

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