Tigar - Trp53 induced glycolysis regulatory phosphatase Gene

Mus musculus

Also known as 9630033F20Rik

Gene ID: 319801 | Gene type: protein coding

About Tigar

Summary

Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in negative regulation of neuron death and response to ischemia. Acts upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Located in mitochondrion. Is expressed in brain; immune system; and liver. Orthologous to human TIGAR (TP53 induced glycolysis regulatory Phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Tigar Products(1)

mRNA	Protein	Name
NM_177003.5	NP_795977.1	fructose-2,6-bisphosphatase TIGAR

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fructose-2,6-bisphosphate 2-phosphatase activity	IMP IMP: Inferred from mutant phenotype	20935145	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within fructose 2,6-bisphosphate metabolic process	IMP IMP: Inferred from mutant phenotype	20935145	MGI
acts upstream of glucose catabolic process to lactate via pyruvate	IMP IMP: Inferred from mutant phenotype	20935145	MGI
acts upstream of glycolytic process	IDA IDA: Inferred from direct assay	20935145	MGI
acts upstream of or within intestinal epithelial cell development	IMP IMP: Inferred from mutant phenotype	23726973	MGI
acts upstream of mitophagy	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within negative regulation of glucose catabolic process to lactate via pyruvate	IMP IMP: Inferred from mutant phenotype	20935145	MGI
acts upstream of or within negative regulation of glycolytic process	IDA IDA: Inferred from direct assay	20935145	MGI
acts upstream of or within negative regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
involved in positive regulation of pentose-phosphate shunt	IDA IDA: Inferred from direct assay	24872551	MGI
acts upstream of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	22044588	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	23726973	MGI
involved in response to ischemia	IDA IDA: Inferred from direct assay	24872551	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	23726973	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24872551	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	24872551	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fructose-2,6-bisphosphatase TIGAR

TP53-induced glycolysis and apoptosis regulator	TP53-induced glycolysis regulatory phosphatase
Trp53 induced glycolysis repulatory phosphatase	probable fructose-2,6-bisphosphatase TIGAR

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1925A	GO-203 TFA		99.28%	Unkown
HY-RS14523	TIGAR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18552	Tigar Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25034	Tigar Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tigar	NCBI	NCBI:57103

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