Fus - Fus RNA binding protein Gene

Rattus norvegicus

Gene ID: 317385 | Gene type: protein coding

About Fus

Summary

Enables ionotropic glutamate receptor binding activity; Myosin V binding activity; and nuclear receptor binding activity. Involved in cellular response to calcium ion. Located in dendritic spine head; perikaryon; and perinuclear region of cytoplasm. Part of polysome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Fus Products(1)

mRNA	Protein	Name
NM_001012137.1	NP_001012137.1	RNA-binding protein FUS

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	19103256	RGD
enables myosin V binding	IPI IPI: Inferred from physical interaction	19103256	RGD
enables nuclear estrogen receptor binding	IDA IDA: Inferred from direct assay	9440806	RGD
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	9440806	RGD
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	9440806	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	19103256	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	15843054	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	15843054	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	15843054	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26834559	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15843054	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	15843054	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15843054	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	26834559	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RNA-binding protein FUS

16) in malignant liposarcoma)	16) malignant liposarcoma
fused in sarcoma RNA binding protein	fusion (involved in t(12
fusion, derived from t(12	fusion, derived from t(12
16) malignant liposarcoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147410	Ulefnersen		94.55%	Phase 3

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147410A	Ulefnersen sodium		94.55%	Unkown
HY-RS05149	FUS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N15496	Fusaproliferin	Inhibitor	/	Unkown
HY-RS17359	Fus Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23813	Fus Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fus	NCBI	NCBI:2521
Macaca fascicularis	Fus	NCBI	NCBI:101925561
Mus musculus	Fus	NCBI	NCBI:233908

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