2. Gene
  3. Ddx3x - DEAD-box helicase 3, X-linked Gene

Ddx3x - DEAD-box helicase 3, X-linked Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 317335 | Gene type: protein coding

About Ddx3x

Summary

Predicted to enable several functions, including helicase activity; nucleic acid binding activity; and nucleoside-triphosphatase activity. Predicted to be involved in several processes, including positive regulation of type I interferon production; regulation of cellular protein metabolic process; and regulation of signal transduction. Predicted to act upstream of or within with a negative effect on primary miRNA processing. Predicted to be located in several cellular components, including centrosome; cytoplasmic stress granule; and nucleoplasm. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in P granule and nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to several human genes including DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Ddx3x Products(2)

mRNA Protein Name
NM_001398751.1 NP_001385680.1 ATP-dependent RNA helicase DDX3X isoform 1
NM_001398752.1 NP_001385681.1 ATP-dependent RNA helicase DDX3X isoform 2
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20131911 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
20131911 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DDX3X

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03646 DDX3X Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17503 Ddx3x Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23960 Ddx3x Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddx3x NCBI NCBI:1654