Tbx18 - T-box transcription factor 18 Gene

About Tbx18

Summary

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; sinoatrial node cell differentiation; and somitogenesis. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and sensory perception of sound. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription repressor complex. Human ortholog(s) of this gene implicated in CAKUT2. Orthologous to human TBX18 (T-box transcription factor 18). [provided by Alliance of Genome Resources, Apr 2022]